association between xpd (lys751g1n) polymorphism and lung cancer risk: a population-based study in iran
نویسندگان
چکیده
objective: people are usually susceptible to carcinogenic aromatic amines, present in cigarrette smoke and polluted environment, which can cause dna damage. therefore, maintenance of genomic dna integrity is a direct result of proper function of dna repair enzymes. polymorphic diversity could affect the function of repair enzymes and thus augment the risk of different cancers. xeroderma pigmentosum group d (xpd) gene encodes one of the most prominent repair enzymes and the polymorphisms of this gene are thought to be of importance in lung cancer risk. this gene encodes the helicase, which is a component of transcription factor iih and an important part of the nucleotide excision repair system. studies reveal that individuals with lys751gln polymorphism of xpd gene have a low repairing capacity to delete the damages of ultraviolet light among other xpd polymorphisms. materials and methods: in this case-control study, first lys751gln polymorphism was genotyped, then its association with lung cancer risk was analyzed. genomic dna was extracted from the whole blood sample of 640 individuals from iran (352 healthy individuals and 288 patients). allele frequencies and heterozygosity of lys751gln polymorphism were determined using polymerase chain reaction-restriction fragment length polymorphism method. results: according to statistical analyses, lung cancer risk in individuals with lys751gln polymorphism (odd ratio=1.8, 95% confidence interval 0.848-3.819) is approximately twice as high as that of lys/lys genotype, however 751gln/gln genotype did not relate to lung cancer risk (odd ratio=0.7, 95% confidence interval 0/307-1/595). conclusion: this study suggests that heterozygous polymorphism (lys/gln) increases the sensitivity of lung cancer risk, while homozygous polymorphism (lys/lys) probably decreases its risk and c allele frequency shows no remarkable increase in the patients.
منابع مشابه
Association between XPD (Lys751G1n) Polymorphism and Lung Cancer Risk: A Population-Based Study in Iran
OBJECTIVE People are usually susceptible to carcinogenic aromatic amines, present in cigarrette smoke and polluted environment, which can cause DNA damage. Therefore, maintenance of genomic DNA integrity is a direct result of proper function of DNA repair enzymes. Polymorphic diversity could affect the function of repair enzymes and thus augment the risk of different cancers. Xeroderma pigmento...
متن کاملNo association between the XPD (Lys751G1n) polymorphism or the XRCC3 (Thr241Met) polymorphism and lung cancer risk.
Introduction DNA repair helps to protect the genome from tobacco-induced damage. Reduced DNA repair capacity may predispose individuals to lung cancer (1). Polymorphisms in genes encoding DNA repair proteins may modulate susceptibility to tobacco lung carcinogens. Bulky DNA adducts induced by chemical carcinogens in cigarette smoke are repaired through the nucleotide excision repair pathway tha...
متن کاملrelationship between xpd lys 751 gln polymorphism and colorectal cancer risk: a case-control study in a population-based study
this study has examined the relationship between the xpd lys 751 gln polymorphism and colorectal cancer in 88 patients and their 88 age and sex-matched controls. genomic dna from peripheral whole blood was extracted using standard method to determine the genotype of subjects with rflp-pcr analysis. although this study shows cancer patients harbor more heterozygous genotype (xpd lys 751 gln) (or...
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15 صفحه اولRelationship between XPD Lys 751 Gln polymorphism and colorectal cancer risk: a case-control study in a population-based study
AIM In our study, we analyzed the allelic frequency of XPD Lys751Gln polymorphism of the XPD gene and the correlation between its variant alleles with colorectal cancer in patients and control groups. BACKGROUND Human cells are routinely exposed to mutagenic and carcinogenic aromatic amines via smoking, pollution areas and other sources. These chemicals can form DNA adducts in vivo and thus l...
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Background: Lung cancer is considered as one of the most frequent cancers worldwide, and has been the cause of more than one <span style="font-variant...
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عنوان ژورنال:
cell journalجلد ۱۶، شماره ۳، صفحات ۳۰۹-۳۱۴
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